![]() ![]() The spike protein (S protein) of SARS-CoV has pivotal roles in viral infection and pathogenesis. The cell entry programs for these viruses are orchestrated by the viral spike (S) proteins that bind cellular receptors and also mediate virus-cell membrane fusions. After entering into respiratory or gastrointestinal tracts, these viruses establish themselves by entering and infecting lumenal macrophages and epithelial cells. The CoVs are widely distributed in nature and their zoonotic transmissions into human populations can cause epidemic disease. The functional role of MHV and SARS-CoV HR was confirmed by mutating key residues and by inhibition experiments using HR2 peptides. For SARS-CoV and MHV, the post-fusion structures of the HR have been solved they form the characteristic six-helix bundle. Heptad repeats comprise a repetitive heptapeptide abcdefg with a and d being hydrophobic residues characteristic of the formation of coiled-coil that participate in the fusion process. Both are able to function as receptor binding domains (RBDs) and bind variety of proteins and sugars.Ĭoronavirus spike proteins contain two heptad repeats in their S2 domain, a feature typical of a class I viral fusion proteins. The S1 contains two subdomains, a N-terminal domain (NTD) and a C-terminal domain (CTD). The S2 subunit is the most conserved region of the protein, whereas the S1 subunit diverges in sequence even among species of a single coronavirus (Figure 2). The formation of an α-helical coiled-coil structure is characteristic of this class of fusion protein, which contain in their C-terminal part regions predicted to have an α-helical secondary structure and to form coiled-coils. ![]() The coronavirus spike protein is a class I fusion protein. This has important consequences on their fusogenicity. Interestingly, within the betacoronavirus mouse hepatitis virus (MHV) species, different strains, such as MHV-2 and MHV-A59 display different cleavage requirements. With some exceptions, in most alphacoronaviruses and the betacoronavirus SARS-CoV, the virions harbor a spike protein that is uncleaved, whereas in some beta- and all gammacoronaviruses the protein is found cleaved between the S1 and S2 domains, typically by furin, a Golgi-resident host protease. Indeed, the recombinant Spike protein can bind with recombinant ACE2 protein.Ī notable distinction between the spike proteins of different coronaviruses is whether it is cleaved or not during assembly and exocytosis of virions. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. CoV diversity is reflected in the variable spike proteins (S proteins), which have evolved into forms differing in their receptor interactions and their response to various environmental triggers of virus-cell membrane fusion. The ectodomain of all CoV spike proteins share the same organization in two domains: a N-terminal domain named S1 that is responsible for receptor binding and a C-terminal S2 domain responsible for fusion (Figure 2). Spike proteins assemble into trimers on the virion surface to form the distinctive "corona", or crown-like appearance. In addition, this protein is highly glycosylated as it contains 21 to 35 N-glycosylation sites. The spike protein (S protein) is a large type I transmembrane protein ranging from 1,160 amino acids for avian infectious bronchitis virus (IBV) and up to 1,400 amino acids for feline coronavirus (FCoV) (Figure 1). Industry Insights with Yuning Chen on Recombinant Proteins.ExpertAnswers: Yuning Chen on Antibody Production.Universal Vaccine Advancement through AI and Recombinant Technology.Nanobodies: An Important Tool for the Next Generation of Tumor Diagnostics and Therapeutics.ExpertAnswers: Amy Sheng on Antibody Screening and Discovery.Recombinant DNA Technology and Its Impact on Drug Discovery.CAR-T Cell Therapy Development: From Personalized to off the Shelf Approaches.BioBuzz with Sino | Episode 1: ChatGPT in Biotech.Special Offer: Custom Recombinant Antibody Production Service.Take Our Short Survey to Win Free Gift !.50% OFF: Antibody Humanization Service & AI-Powered Antibody Affinity Maturation Service.Common Cytokine Receptor Signaling Pathway.Multi-pass Transmembrane Protein Development.Beacon ® Single B Cell Screening Service. ![]()
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![]() It’s an updated version of bro, or brother. Often shortened to “Bruh…” and delivered under the breath. Bruh moment – The bruh moment is a bad situation in which it would be appropriate to express disappointment, shock, disbelief or empathy.gif or image to show how you’re feeling (circa 2018 and still used ironically). ![]() Big mood – means that what you’re going through is relatable is often paired with a meme.This term’s getting dated, but still seems to be hanging tough. ![]()
![]() ![]() The Keemun and Lapsang Souchong are the first black teas exported to foreign markets. Chinese black teas are mainly produced in Fujian and Yunnan. Not strange, given the relatively short history of this category. The black tea list is much shorter than the green tea list above. Official NameĮn Shi Gyokuro, En Shi Green Dew, En Shi Jade Dew We've also added the related English tea names, when available. The main stars in this category are the Xi Hu Long Jing, Bi Luo Chun and Huang Shan Mao Feng, which you see often appear in top 10 Chinese tea lists. The most famous green teas come from the province Zhejiang and Anhui. Green Tea - Black Tea - Oolong Tea - White Tea - Yellow Tea - Pu Erh Tea - Herbal TeaĪmong all the tea types, the list of Chinese green teas is definitely the longest. Tea Type Names ListĬlick on one of the tea type links below to go directly to the list that you're interested in. We're more than happy to add it and further improve this tea names list. If you see any teas missing, let us know. As you can see below the list is long, which isn't surprising due to the long tea history of China. It's known by it's English tea names such as 'Iron Buddha' or 'Iron Goddess' while at the same time known in different variations of romanisation such as 'Ti Kuan Yin', 'Tit Kwun Yum', and 'Ti Kwan Yin'.īecause of this issue, we've decided to compile a complete list of teas from China, categorised per tea type. ![]() Take for example Tie Guan Yin, which is a type of oolong from Fujian province. The latter becomes even more confusing when different romanisation systems are used for different teas such as Cantonese and Mandarin. Some teas are listed on websites based on direct English translations, while others are written based on 'pinyin' (Chinese written in Western letters). □ See Cantonese Input for Android Phones (Samsung, Google Pixels, HTC, etc.There's a bit confusion these days with regards to the names of Chinese teas.□ See Cantonese Input for iPhones and iPads.□ See Cantonese Input for Apple Laptops (Macbooks and Macs).Different devices have different options. There are several Ping³jam¹ (pinyin) input methods for Cantonese. To convert more characters, it costs 75 HKD (8 £) per month, or 230 HKD (25 £) for lifetime access. The free version is limited to converting 25 characters. Converts 廣東話 to Guangdong Romanisation (guong2 dung1 ping3 yem1 fong1 on3 | 廣東拼音方案)Įasy Pronunciation is a paid service that offers phonetic translators and recordings. ![]() ![]()
![]() If you or your organization would like to use Celebration Station for your activity or event, use the buttons at top to learn about Albion's Special Events policy and/or submit an application. The STAR Team's vision for the continued development of Celebration Station is more beautification, including murals/backdrops, that will help anyone see that downtown Albion is THE place to get together and celebrate almost any occasion, including birthdays, anniversaries, proposals, reunions, new product/store launches, games, and more! A couple of benches and flowering pots were added in the fall, just in time for the beginning of the Make It Your Own Mural Fest that brought the Doc's Fox to town.Īs 2021 rolls forward, and with the HCI Team's work complete, the Albion STAR Team is assisting the Town of Albion by promoting the alley, now called "Celebration Station", to further activate this new space and bring people downtown! Overhead "Edison-style" lighting was added for ambience and after-dark events. More upgrades were made in 2020 with the installation of a custom-fabricated railroad-style crossing bar that can serve to close the alley from incoming traffic when used for special events. In 2019 the alley surface was upgraded and painted to look like a railroad track to complement the Pizza Depot's theme, and their plans to install some wall art on the side of their building. Inside enjoy laser tag, and a two story arcade. Outside attractions include go-karts, bumper boats, miniature golf, playland rides, batting cages, and eurobungy. Celebration Station serves pizza, steak subs, burgers, chicken salad, wings, kid meal options, and more. Albion's HCI Team ultimately chose "Placemaking" and decided to complete an "alley activation" to give more purpose to an often vacant downtown space and enable a place for community to gather and engage downtown. Specialties: Celebration Station Clearwater, FL offers both indoor and outdoor attractions, two story video arcade, and restaurant. They learned, together, how to facilitate community conversations, how to prioritize, and how to reach consensus.Īt the end of this learning process came a "Capstone Project". Over the following year more people joined the conversation with the core HCI Team. A variety of outcomes were possible, including the development of retail options, restaurants, and recreational spaces development of leadership to take Albion into the future and economic development. As an HCI Community, Albion benefitted from having community development professionals from OCRA, Ball State University, and Purdue University coach several volunteers who made up the HCI Team on how to reach goals identified by listening to citizens.Ī survey was conducted first, then the public forum was held. This was the first step in a process that Albion was chosen, as one of just five communities in the State of Indiana, to participate in by the Indiana Office of Community and Rural Affairs (OCRA). I’m giving three stars because none of the employees there seemed to have any idea what was going on.In 2017, everyone who lived, worked, or played in the greater Albion area was invited to participate in a community forum because input was being sought from the public to aid the Albion Hometown Collaboration Initiative (HCI) Team in identifying a community development project to encourage “placemaking”, leadership, and/or economic growth in Albion. We stuck outside this time but they have tons of games and laser tag as well. We got the grill chicken sandwich and grill chicken salad. Unbiased, genuine user reviews, ratings and experience for Party 360 Degrees The. I wasn’t expecting too much from the food. Reviews for Party 360 Degrees The Celebration Station, Tonk Road, JAIPUR. When we had busy days there wasn’t much conflict with the guests. When it was slow I was usually cleaning picking up trash. ![]() Overall my working experience was greta at Celebration Station. The track is a good size and the kids had a lot of fun. Celebration Station is the place with the most ways to play. Babysitting, Davis Residence - Babysitter (Current Employee) - Mesquite, TX 75150 - August 20, 2019. It wasn’t busy so they never had to wait, they just kept going. The kids pretty much never left the go-carts then entire time. Celebration Station is pleased to offer personalized candy wrappers, labels, invitations, pinback buttons and a ton of party favors for your special event. Make sure you are paying for exactly what you want because some activities (such as the trampoline) are not included. Come to find out that they were not all included. ![]() We specifically asked if all the outdoor activities were included and the worker said yes. We went with the all-day outdoor activities with food. You can add games, outdoor activities and meals, depending on what you want. There are a bunch of bundle deals that you can choose from. It wasn’t too busy so I was happy about that. Came here on a Saturday morning with my boyfriend and his niece and nephew. ![]() ![]() The Summer Solstice celebrates the abundance of the earth, at a time when nature is ripe, flourishing with offerings of life. The term ‘ solstice’ is derived from the Latin words for “sun standing still”, and refers to the point at which the sun’s visual trajectory north or south across the horizon comes to a halt. In the Southern hemisphere conversely, the sun reaches it’s southernmost point in the sky, marking the midpoint of Winter, and is known as Winter Solstice. ![]() ![]() The longest day and shortest night of the year occur on this date, marking the beginning of summer, and is known as Summer Solstice, or Midsummer. On the 21st June in the Northern Hemisphere the sun reaches its northernmost point in the sky, reaching the height of its power. What’s not to like? What is the Summer Solstice? The warmer Months bring with it a carefree sense of freedom, an expansive energy that propels me into action as I spend more time outdoors replenishing under the full force of the Suns ray’s. Summer can also signal a time of sizzling summer ROMANCE, PASSION, CREATIVITY, ABUNDANCE, and HAPPINESS. Whilst each season possesses its own unique beauty, as someone living in the Northern hemisphere, Summer holds a particularly special place in my heart. The result a celebration of abundance and joy as the natural world explodes into full bloom lush with trees, flowers and fruits blossoming to their full potential and unfurling in a kaleidoscope of colours. All the upward energy of Spring spirals to its peak and launches us into Summer, when the days are longer than the nights. As the wheel of the year turns to Summer, we enter into a time of fruition and fulfilment. ![]() ![]() The main constraint here is weight and size, so the goal is to get as much energy as possible within a power pack that’s still reasonable for extended foot travel.ġ0,000mAh to 20,000mAh is the current sweet spot of energy density and portability. High energy density (storage capacity per ounce of weight) that’s portable enough for a go-bag. But in an emergency, you don’t know when you’ll get grid access again, so you’ll want to use your power bank in ways that maximize its storage capacity and long-term health. In daily life, most people use these power banks for a quick single-device top-up when they can’t find a wall plug. Lifespan and capacity are more important than convenience. That context matters, because it leads to choices that are different than for typical business travel, camping, or everyday carry needs. To pick which products to buy for this review, and which are the winners, we first think about what things will be like in an emergency and how you’ll actually use these power banks when you need them most. No one-pack solution in this review gives you this level of flexibility for optimizing charge speed and battery life. So with those two chargers and four port options, you can decide if you want to charge slowly over USB-A or Micro-USB (for more battery life), a little faster over 12W USB-A, or really fast over 18W USB-C (for less battery life). For example, the NOVOO has a pair of slow-charging 7.5W USB-A and Micro USB ports, plus a fast-charging 18W USB-C port while the Anker has a fast-charging 12W USB-A port. You also increase your safety and flexibility by carrying two different models/brands. The weight penalty is usually just 1-2 oz compared to a single pack, for example.Ĭombined with the benefits from having two of something instead of one, we now personally carry both the NOVOO and Anker 10,000 mAh. energy density), size, weight, and cost as a single 20k pack. The way these packs are built means that two 10k packs are about the same capacity-to-weight ratio (ie. Left to right: NOVOO Explorer, Anker PowerCore 10k, Anker PowerCore II 20k, HX160Y6īigger is always better with batteries, so we’d normally try to steer you toward a 20,000mAh pack if you’re someone who can afford to dedicate as much as 12oz of pack weight to a USB charger.īut in this case, unless you really need the big pack (see next pick), we’re taking the unusual step of suggesting you carry two 10,000mAh packs instead of one big pack. You’ll pay a premium for the Anker name and higher capacity per ounce, though, and it’s not as outdoors-friendly as the NOVOO. The unit’s single USB-A dedicated output port has PowerIQ circuitry that can charge at up to 12W if you need a quicker charge. It’s also backed by Anker’s well-established reputation for quality and support. This 6.35-ounce power pack is the smallest and lightest 10,000mAh charger we tested. If you’re looking to keep your weight budget to the absolute minimum while still carrying enough charge to refill an iPhone three or four times, then the best ultra compact bank is the Anker PowerCore 1000. This is the lightest and most compact charger we tested, so it's perfect for when weight and space are at a premium. One warning about NOVOO: this is an Amazon-only Chinese seller, so don’t have high expectations for support if something’s wrong with the unit (although Amazon will step up if you have a problem within the return window). But if you do need a fast charge, the USB-C port can do 18W charging via the power delivery (PD) protocol. The lone USB-A port is only 7.5W, but that low wattage is a good thing for prepping purposes, because you can drain the pack more slowly to squeeze more energy from it. The NOVOO is very reasonably priced, and it delivered plenty of charge in our electrical testing. More: Learn the basics of off-grid power and prepper tips for batteries. It’s waterproof (which we validated in a dunk test), the LED light is legitimately useful, and the rugged design does add durability without costing much more money or weight. Although we generally think “survival” features in these kinds of products are a gimmick to avoid, such as built-in lights or compasses that are only designed to get you to click “Buy,” in this case the NOVOO won us over. If you only buy one thing, check out the NOVOO Explorer 10,000mAh, a top performer both on paper and in our own performance review. It's lightweight and packable, and the price really low so the value is off the charts. This outdoors-friendly power bank stores plenty of charge and can handle submersion in water. ![]() ![]() Due to safety requirements, Lower noise and energy-efficient. What’s more, the submersible pump impeller blade features highly corrosion-resistant impeller that automatically adjusts to speed and fluid viscosity to ensure long service life. 【HIGH-QUALITY MATERIALS】: Full corrosion-resistant shell and environmental thermoplastic construction ensure less prone to mechanical failure.Additionally, the pump comes with a 10-foot power cord and detachable suction filter that can handle solids up to 1/8 inch thick. 【EFFICIENT UTILITY PUMP】: High-efficiency submersible water pump with 1/3HP power motor discharges up 2450 Gallon Per Hour (40.8 gallons per minute) and has a maximum lift capacity of 28 feet, easily tackling any draining job at a fraction of the time.It can effectively avoid the water in the bird bath from flowing dry quickly. 3 WATER FLOW HEIGHTS: According to the feedback of most customers, we designed 3 gears on the pump, which are low, medium, and high.EASY TO USE: Just put in the water, the pump will start to work in 3s once exposed to sufficient sunlight, perfect for bird bath, fish tank, small pond, pool, garden decoration, water circulation for oxygen.SPRAYER FOR DIFFERENT WATER STYLE: The package comes with 6 nozzles, which allows you to choose different water fountain patterns easily, adding much fun into your garden.It prevents the solar powered water fountain from spraying water outside the bath and empties water quickly. KEEPING THE PUMP IN THE MIDDLE OF THE BIRD BATH: Our company has designed a retainer to avoid the random movement of the solar fountain pump.The most important this will attract a lot of hummingbirds to your garden! ![]()
![]() Try it : Firstly, install external library arduinoSockets.h Install my library WiFiTerm. Its use goes through the same functions as the Serial terminal. It’s a standard Internet Protocol (IP) for synchronizing the computer clocks to some reference over a network. bricoleau March 22, 2020, 7:04pm 1 Hello Here is a web terminal, to 'stay in touch' with an ESP, even when it is no longer connected to your computer. Step 2: What Is a NTP and How It Will Work What is a NTP : An NTP stands for Network Time Protocol. In terms of development, what I tend to do is something like this in the right of the web terminal: var exports = Įxports. Step 1: Things You Need For this project you'll need very few things : ESP8266/NODEMCU A USB cable to program it. ![]() ![]() In addition, you can control the Espruino from almost. If it's moving pins up and down you need to give it a bit more thought because ideally you want to be using setWatch to respond to events on pins.Ī good start would be looking at the existing modules in: /tree/master/devices It allows for quick and easy debugging and is a great way to test your project before your big reveal. It depends on what it is - if it's SPI or I2C the commands are pretty similar, so all you're really doing is changing C to JavaScript. GitHub - espruino/Espruino: The Espruino JavaScript interpreter - Official Repo master 10 branches 71 tags Go to file gfwilliams Merge pull request 2378 from bobrippling/readjson-ts bc52028 13 hours ago 8,486 commits. ![]() ![]() ![]() Our efforts are leading to a better quality of life for people with Medicare, families, individuals, military service personnel, and communities at large. Our successful history in care delivery and health plan administration is helping us create a new kind of integrated care with the power to improve health and well-being and lower costs. is committed to helping our millions of medical and specialty members achieve their best health. ![]() More information about Seniorlink can be found at About Humana to receive NCQA Case Management Accreditation with Long Term Services and Support Distinction. Seniorlink’s Caregiver Homes Network is the first Home and Community Based Services (HCBS) organization in the U.S. Backed by nearly two decades of care expertise, Seniorlink leads the way on delivering high quality care. Seniorlink’s team of compassionate, experienced professionals uses a proprietary platform, Vela, to encourage real-time collaboration among the extended care team that results in better outcomes at a lower cost. The company serves patients and caregivers by partnering with risk-bearing provider and payer organizations to augment existing care management capabilities through solutions that leverage human touch and technology. Seniorlink is a tech-enabled health services company that builds care collaboration solutions. To learn more about Seniorlink, visit About Seniorlink “By working on this pilot with Seniorlink, we hope to keep learning and building on best practices to help our Medicare Advantage members experience their highest quality of life in their own homes.” ![]() “Humana remains committed to the long-term health of our members and to helping seniors across the country achieve their best possible health,” said Cheri Greenfield La Tour, Humana Senior Vice President of Home Care Operations. The six-month pilot will include up to 250 Humana Medicare Advantage members and family caregivers in 34 states across the country. “We are pleased to collaborate with Humana, a respected, innovative industry leader, that shares our commitment to supporting family caregivers and our vision of leveraging technology to impact care delivery for complex individuals,” stated Tom Riley, President and CEO of Seniorlink. By reducing barriers to contact and increasing the overall engagement of a care team, Vela has helped to improve the satisfaction of members and family caregivers, alleviate caregiver burden and reduce overall cost of care. Vela, Seniorlink’s secure collaboration app, allows care teams, members and family caregivers to communicate and collaborate more effectively. Humana At Home is a division of Humana that identifies and supports Humana Medicare Advantage members who have multiple chronic conditions, struggle with daily activities and are frequently hospitalized, as well as their family members and caregivers. The pilot is designed to allow Humana At Home care management teams to connect digitally with Humana Medicare Advantage members and their families, so that members with medical and functional challenges can maintain their independence and receive support at home. ![]() 17, 2019 /PRNewswire/ - Seniorlink, Inc., a leading tech-enabled health services company, is pleased to announce a Virtual Care Team pilot with leading health and well-being company Humana Inc. (NYSE: HUM), focused on providing additional care management to the company’s Medicare Advantage members. By Laurie Gillis, Vice President, Marketing on 2:43:00 PMīOSTON, Sept. ![]() ![]() Headline: SEC Shuts Down WeedGenics $60 Million Cannabis Offering Fraud Headline: Former Coinbase Manager and His Brother Agree to Settle Insider Trading Charges Relating to Crypto Asset Securities Headline: Former Wells Fargo Senior Executive Carrie Tolstedt Agrees to Settle SEC Fraud Charges for Misleading Investors About Abusive Sales Practices to Inflate a Key Performance Metric Headline: Small Business Advisory Committee June Meeting to Focus on Capital Raising and Reducing Funding Gaps for Underrepresented Founders Headline: SEC Files 13 Charges Against Binance Entities and Founder Changpeng Zhao Headline: SEC Charges Coinbase for Operating as an Unregistered Securities Exchange, Broker, and Clearing Agency Headline: SEC Seeks Emergency Relief to Ensure Binance.US Customers’ Assets are Protected Headline: SEC Adopts Rules to Prevent Fraud in Connection with Security-Based Swaps Transactions and Prevent Undue Influence over CCOs Headline: SEC Adopts Amendments to Remove References to Credit Ratings From Regulation M Headline: SEC Unveils New Public Service Campaign Encouraging Older Investors to Never Stop Learning Headline: SEC Charges Investment Adviser and Principal in Abusive Naked Short Selling Scheme Headline: Michele Layne, Director of Los Angeles Regional Office, to Leave SEC Headline: SEC Charges PIMCO for Disclosure and Policies and Procedures Failures Headline: SEC Secures Emergency Relief to Protect Binance.US Customers’ Assets Headline: SEC Charges Stanley Black & Decker and Former Executive for Failures in Executive Perks Disclosure Headline: SEC Charges Private Equity Fund Adviser for Overcharging Fees and Failing To Disclose Fee Calculation Conflict Headline: SEC Reopens Comment Period for Position Reporting of Large Security-Based Swap Positions Headline: SEC Charges Audit Firm Marcum LLP for Widespread Quality Control Deficiencies ![]() Headline: SEC Investor Advisory Committee to Discuss Private Funds and Outbound Investments to Countries of Concern, Digital Engagement Practices, and Audit Committee Workloads at June 22nd Meeting ![]() Headline: SEC Charges Investment Fund Founder William K. Headline: SEC Charges Convicted Fraudster in Real Estate Ponzi Scheme ![]() |
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